Recent papers

A multiplexed, single-cell sequencing screen identifies compounds that increase neurogenic reprogramming of murine Müller glia. Tresenrider, A., Hooper, M., Todd, L., Kierney, F., Blasdel, N., Trapnell, C., Reh, TA. eLife. 2024 Jun 13; PMID: 37808650

The impact of timing and injury mode on induced neurogenesis in the adult mammalian retina. Pavlou, M., Probst, M., Blasdel, N., Prieve, AR., Reh, TA. Stem Cell Reports. 2024 Feb 13; 19 (2): 239-253. PMID: 38278154

ASCL1 induces neurogenesis in human Müller glia. Wohlschlegel, J., Finkbeiner, C., Hoffer, D., Kierney, F., Prieve, AR., Murry, AD., Haugan, AK., Ortuño-Lizarán, I., Rieke, F., Golden, SA., Reh, TA. Stem Cell Reports, 2023 Dec 23; 2;18(12):2400-2417. PMID: 38039971

Cell-Based Therapies: Strategies for Regeneration. Pavlou, M., Reh, TA. Cold Spring Harb Perspect Biol. 2023 Mar 6: a041306. doi: 10.1101/cshperspect.a041306. Online ahead of print. PMID: 36878647

Reprogramming Müller glia to regenerate ganglion-like cells in adult mouse retina with developmental transcription factors. Todd, L, Jenkins, W., Finkbeiner, C., Hooper, M., Donaldson, P., Pavlou, M., Wohlschlegel, J., Ingram, N., Rieke, F., Reh T. Sci Adv. 2022 Nov 23;8(47). PMID: 36417510.

Single-cell ATAC-seq of fetal human retina and stem-cell-derived retinal organoids shows changing chromatin landscapes during cell fate acquisition. Finkbeiner C, Ortuño-Lizarán I, Sridhar A, Hooper M, Petter S, Reh TA. Cell Rep. 2022 Jan 25;38(4):110294. doi: 10.1016/j.celrep.2021.110294. PMID: 35081356.

Efficient stimulation of retinal regeneration from Müller glia in adult mice using combinations of proneural bHLH transcription factors Todd, L, Hooper, M.J., Haugan, A.K., Finkbeiner, C., Jorstad, N., Radulovich, N., Wong, C.K., Donaldson, P.C., Jenkins, W., Chen, Q., Rieke F., Reh, T.A. Cell Reports. 2021 Oct 19; 37 (3): 109857. PMID: 34686336

Comparative Biology of Vertebrate Retinal Regeneration: Restoration of Vision through Cellular Reprogramming. Todd L, Reh TA. Cold Spring Harb Perspect Biol. 2021 Sep 27:a040816. doi: 10.1101/cshperspect.a040816. Epub ahead of print. PMID: 34580118.

Human retinal model systems: Strengths, weaknesses, and future directions. Eldred KC, Reh TA. Dev Biol. 2021 Sep 13;480:114-122. doi: 10.1016/j.ydbio.2021.09.001. Epub ahead of print. PMID: 34529997.

Microglia suppress Ascl1-induced retinal regeneration in mice. Todd, L., Finkbeiner, C., Wong, C.K., Hooper, M.J. Reh, T.A. Cell Reports. 2020 Dec 15; 33 (11): 108507. PMID: 33326790

Developmental changes in the accessible chromatin, transcriptome and Ascl1-binding correlate with the loss in Müller Glial regenerative potential. Vandenbosch, L.V., Wohl, S.G, Wilken, M.S., Hooper, M.J., Finkbeiner, C., Cox, K., Chipman, L. Reh. T.A. Scientific Reports. 2020 Aug 12;10(1):13615. doi: 10.1038/s41598-020-70334-1.

Single-Cell Transcriptomic Comparison of Human Fetal Retina, hPSC-Derived Retinal Organoids, and Long-Term Retinal Cultures. Sridhar A, Hoshino A, Finkbeiner CR, Chitsazan A, Dai L, Haugan AK, Eschenbacher KM, Jackson DL, Trapnell C, Bermingham-McDonogh O, Glass I, Reh TA. Cell Rep. 2020 Feb 4;30(5):1644-1659.e4. doi: 10.1016/j.celrep.2020.01.007. PMID: 32023475

STAT Signaling Modifies Ascl1 Chromatin Binding and Limits Neural Regeneration from Muller Glia in Adult Mouse Retina. Jorstad NL, Wilken MS, Todd L, Finkbeiner C, Nakamura P, Radulovich N, Hooper MJ, Chitsazan A, Wilkerson BA, Rieke F, Reh TA. Cell Rep. 2020 Feb 18;30(7):2195-2208.e5. doi: 10.1016/j.celrep.2020.01.075. PMID: 32075759

Rehlab: most cited and trending (<2020)

1.Molecular Anatomy of the Developing Human Retina.Hoshino A, Ratnapriya R, Brooks MJ, Chaitankar V, Wilken MS, Zhang C, Starostik MR, Gieser L, La Torre A, Nishio M, Bates O, Walton A, Bermingham-McDonogh O, Glass IA, Wong ROL, Swaroop A, Reh TA.Dev Cell. 2017 Dec 18;43(6):763-779.e4. doi: 10.1016/j.devcel.2017.10.029. Epub 2017 Dec 7.PMID: 29233477

2.Müller glial microRNAs are required for the maintenance of glial homeostasis and retinal architecture.Wohl SG, Jorstad NL, Levine EM, Reh TA.Nat Commun. 2017 Nov 17;8(1):1603. doi: 10.1038/s41467-017-01624-y.PMID: 29150673

3.Stimulation of functional neuronal regeneration from Müller glia in adult mice.Jorstad NL, Wilken MS, Grimes WN, Wohl SG, VandenBosch LS, Yoshimatsu T, Wong RO, Rieke F, Reh TA.Nature. 2017 Aug 3;548(7665):103-107. doi: 10.1038/nature23283. Epub 2017 Jul 26.PMID: 28746305

4.Synchrony and asynchrony between an epigenetic clock and developmental timing.Hoshino A, Horvath S, Sridhar A, Chitsazan A, Reh TA.Sci Rep. 2019 Mar 6;9(1):3770. doi: 10.1038/s41598-019-39919-3.PMID: 30842553

5.MicroRNAs miR-25, let-7 and miR-124 regulate the neurogenic potential of Müller glia in mice.Wohl SG, Hooper MJ, Reh TA.Development. 2019 Aug 5. pii: dev.179556. doi: 10.1242/dev.179556.

6.Retinal regeneration in birds and mice.Wilken MS, Reh TA.Curr Opin Genet Dev. 2016 Oct;40:57-64. doi: 10.1016/j.gde.2016.05.028. Epub 2016 Jul 2. Review.PMID: 27379897

7.Transgenic expression of the proneural transcription factor Ascl1 in Müller glia stimulates retinal regeneration in young mice.Ueki Y, Wilken MS, Cox KE, Chipman L, Jorstad N, Sternhagen K, Simic M, Ullom K, Nakafuku M, Reh TA.Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13717-22. doi: 10.1073/pnas.1510595112. Epub 2015 Oct 19.PMID: 26483457

8.DNase I hypersensitivity analysis of the mouse brain and retina identifies region-specific regulatory elements.Wilken MS, Brzezinski JA, La Torre A, Siebenthall K, Thurman R, Sabo P, Sandstrom RS, Vierstra J, Canfield TK, Hansen RS, Bender MA, Stamatoyannopoulos J, Reh TA.Epigenetics Chromatin. 2015 Feb 28;8:8. doi: 10.1186/1756-8935-8-8. eCollection 2015.PMID: 25972927

9.A transient wave of BMP signaling in the retina is necessary for Müller glial differentiation.Ueki Y, Wilken MS, Cox KE, Chipman LB, Bermingham-McDonogh O, Reh TA.Development. 2015 Feb 1;142(3):533-43. doi: 10.1242/dev.118745.PMID: 25605781

10.Conserved microRNA pathway regulates developmental timing of retinal neurogenesis.La Torre A, Georgi S, Reh TA.Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):E2362-70. doi: 10.1073/pnas.1301837110. Epub 2013 Jun 10.PMID: 23754433

11.ASCL1 reprograms mouse Muller glia into neurogenic retinal progenitors.Pollak J, Wilken MS, Ueki Y, Cox KE, Sullivan JM, Taylor RJ, Levine EM, Reh TA.Development. 2013 Jun;140(12):2619-31. doi: 10.1242/dev.091355. Epub 2013 May 1.PMID: 23637330

12.Regulated reprogramming in the regeneration of sensory receptor cells.Bermingham-McDonogh O, Reh TA.Neuron. 2011 Aug 11;71(3):389-405. doi: 10.1016/j.neuron.2011.07.015. Review.PMID: 21835338

13.Genome-wide analysis of Müller glial differentiation reveals a requirement for Notch signaling in postmitotic cells to maintain the glial fate.Nelson BR, Ueki Y, Reardon S, Karl MO, Georgi S, Hartman BH, Lamba DA, Reh TA.PLoS One. 2011;6(8):e22817. doi: 10.1371/journal.pone.0022817. Epub 2011 Aug 2.PMID: 21829655

14.Dicer is required for the maintenance of notch signaling and gliogenic competence during mouse retinal development.Georgi SA, Reh TA.Dev Neurobiol. 2011 Dec;71(12):1153-69. doi: 10.1002/dneu.20899.PMID: 21542136

15.Dicer is required for the transition from early to late progenitor state in the developing mouse retina.Georgi SA, Reh TA.J Neurosci. 2010 Mar 17;30(11):4048-61. doi: 10.1523/JNEUROSCI.4982-09.2010.PMID: 20237275

16.Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development.Brzezinski JA 4th, Lamba DA, Reh TA.Development. 2010 Feb;137(4):619-29. doi: 10.1242/dev.043968.PMID: 20110327

17.Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice.Lamba DA, Gust J, Reh TA.Cell Stem Cell. 2009 Jan 9;4(1):73-9. doi: 10.1016/j.stem.2008.10.015.PMID: 19128794

18.Stimulation of neural regeneration in the mouse retina.Karl MO, Hayes S, Nelson BR, Tan K, Buckingham B, Reh TA.Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19508-13. doi: 10.1073/pnas.0807453105. Epub 2008 Nov 25.PMID: 19033471

19.Neural regeneration and cell replacement: a view from the eye.Lamba D, Karl M, Reh T.Cell Stem Cell. 2008 Jun 5;2(6):538-49. doi: 10.1016/j.stem.2008.05.002. Review.PMID: 18522847

20.Efficient generation of retinal progenitor cells from human embryonic stem cells.Lamba DA, Karl MO, Ware CB, Reh TA.Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12769-74. Epub 2006 Aug 14.PMID: 16908856

21.Making the gradient: thyroid hormone regulates cone opsin expression in the developing mouse retina.Roberts MR, Srinivas M, Forrest D, Morreale de Escobar G, Reh TA.Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6218-23. Epub 2006 Apr 10.PMID: 16606843

22.Downregulation of Otx2 in the dedifferentiated RPE cells of regenerating newt retina.Sakami S, Hisatomi O, Sakakibara S, Liu J, Reh TA, Tokunaga F.Brain Res Dev Brain Res. 2005 Mar 22;155(1):49-59.PMID: 15763275

23.Neurodevelopmental control by thyroid hormone receptors.Forrest D, Reh TA, Rüsch A.Curr Opin Neurobiol. 2002 Feb;12(1):49-56. Review.PMID: 11861164

24.Müller glia are a potential source of neural regeneration in the postnatal chicken retina.Fischer AJ, Reh TA.Nat Neurosci. 2001 Mar;4(3):247-52.PMID: 11224540

25.Identification of a proliferating marginal zone of retinal progenitors in postnatal chickens.Fischer AJ, Reh TA.Dev Biol. 2000 Apr 15;220(2):197-210.PMID: 10753510

26.A thyroid hormone receptor that is required for the development of green cone photoreceptors.Ng L, Hurley JB, Dierks B, Srinivas M, Saltó C, Vennström B, Reh TA, Forrest D.Nat Genet. 2001 Jan;27(1):94-8.PMID: 11138006

27.Hypoxia induces re-entry of committed cells into pluripotency. Mathieu J, Zhang Z, Nelson A, Lambda DA, Reh TA, Ware C, Ruohola-Baker H. Stem Cells. 2013;31(9):1737-48.

28.EGF stimulates müller glial proliferation via a BMP-dependent mechanism. Ueki Y, Reh TA. Glia. 2013 Jan 30. doi: 10.1002/glia.22472. [Epub ahead of print].PMID:23362023